Department of Clinical Haematology, Manchester Royal Infirmary, Manchester, UK.
Hematol Oncol Clin North Am. 2011 Apr;25(2):359-78, viii-ix. doi: 10.1016/j.hoc.2011.01.007.
Pregnancy, childbirth, and the puerperium are hemostatically challenging to women with bleeding disorders. This article provides general recommendations for the management of pregnant women with inherited coagulation disorders. Each factor deficiency is discussed, providing an up-to-date review of the literature and, where possible, guidance about how to manage patients throughout pregnancy, delivery, and the puerperium. The factor deficiencies covered are inherited abnormalities of fibrinogen; deficiencies of prothrombin, factor (F)V, FVII, FX, FXI, FXIII; combined deficiencies of FV and FVIII; and the inherited deficiency of vitamin K-dependent clotting factors. The management of carriers of hemophilia A and B is also discussed.
妊娠、分娩和产褥期对患有出血性疾病的女性具有止血挑战性。本文提供了一般建议，用于管理患有遗传性凝血障碍的孕妇。讨论了每种因子缺乏症，提供了有关纤维蛋白原遗传异常、凝血酶原、因子（F）V、FVII、FX、FXI、FXIII 缺乏症、FV 和 FVIII 联合缺乏症以及维生素 K 依赖性凝血因子遗传性缺乏症的最新文献综述，并尽可能提供了如何在整个妊娠、分娩和产褥期管理患者的指导。还讨论了血友病 A 和 B 携带者的管理。
