Serum lipid and lipoprotein profile abnormality in predicting the risk of coronary artery disease in non-diabetic patients attending NMCTH, Birgunj.

Dyslipidemia is one of the primary causes for coronary artery disease (CAD). Elevated total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C) and lowered high-density lipoprotein-cholesterol (HDL-C) are conventional risk factor in myocardial infarction patients. The present study was undertaken with an objective to frame out the lipid and lipoprotein profile in non-diabetic patients attending OPD of NMCTH, Birgunj. Out of 599 total patients, 317 patients were male and 282 patients were female. The mean +/- SD (mg/dl) levels of lipid, lipoprotein and their ratio among different age group were found increased with increasing age and these were statistically significant when compared with healthy control group. Desirable TC level (<200 mg/dl) in 73.0%, normal TG level (<150 mg/dl) in 59.0%, optimal level of HDL-C (<40 mg/dl) in 82.0% and normal LDL-C (<129 mg/dl) in 32.0% were found of the total population. Nearly 16% population in total, male and female had normal (40-60 mg/dl) HDL-C respectively. Higher percentage of female (46.8%) than male (34.9%) had optimal level of LDL-C (<100 mg/dl). About 20.0% male had very high level of LDL-C (>160 mg/dl) while it was noted in 6.7% of female patients. Higher ratio of TC/HDL-C in both male and female patients was observed compared to controls and it was highest among >70 years age group. Higher ratio of LDL-C/HDL-C of all age group in male patients was observed when compared with control and it was statistically significant while in female patients the ratio was found increased significantly (p<0.05) after the age of 50 years. The study concludes that the importance of assessing the lipid profile and their ratio even in a normal individual as these are atherogenic factors for development of myocardial infarction and other coronary complications. The practice of computing the ratio should be practiced even in a normal health check up packages.