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伴有肺血管阻力升高的室间隔缺损双瓣补片闭合术:AFIC/NIHD的经验

Double flap patch closure of VSD with elevated pulmonary vascular resistance: an experience at AFIC/NIHD.

作者信息

Janjua Asif Mahmood, Saleem Kamal, Khan Inamullah, Rashid Azhar, Khan Asif Ali, Hussain Abid

机构信息

Department of Cardiac Surgery, Armed Forces Institute of Cardiology, National Institute of Heart Diseases, Rawalpindi.

出版信息

J Coll Physicians Surg Pak. 2011 Apr;21(4):197-201.

Abstract

OBJECTIVE

To determine the 30 days outcome measured in terms of morbidity and mortality in cases of ventricular septal defect (VSD) with increased pulmonary vascular resistance (PVR) managed with double flap patch closure.

STUDY DESIGN

Case series.

PLACE AND DURATION OF STUDY

Armed Forces Institute of Cardiology (AFIC/NIHD), Rawalpindi, from December 2005 to December 2008.

METHODOLOGY

Forty patients with VSD having PVR 9.58 + 4.33 wood units underwent double flap patch closure. The patch was fenestrated as one half of the expected aortic annulus diameter. A separate flap patch 5 mm larger than fenestration was attached to superior upper one third margins of fenestration. The patch was placed with flap to open towards the left ventricular apex. Modified ultra filtration (MUF) was employed in every case and sildenafil was given postoperatively.

RESULTS

The age of patients ranged from 1 to 28 years with a mean of 6.66 + 5.70 years. There were 22 males and 18 females. All patients were weaned off from inotropic and ventilatory support as earlier as possible postoperatively with intensive care unit (ICU) stay of 77.15 + 54.56 hours. Postoperative pulmonary artery pressures were reduced to 42.63 + 10.86 mmHg as compared to pre-operative pulmonary artery pressures of 88.3 + 15.2 mmHg. Postoperatively 11 patients with suprasystemic pulmonary artery pressures and desaturation went into pulmonary hypertensive crisis in which immediate 2D echo evidenced the functioning flap valve with right to left shunt. There was only one death (early) out of 40 patients with an overall mortality of 2.5% along with limited morbidity.

CONCLUSION

Double flap patch is an inexpensive, easy to construct technique with low morbidity and mortality in cases of VSD with raised PVR.

摘要

目的

确定采用双瓣补片闭合术治疗的伴有肺血管阻力(PVR)升高的室间隔缺损(VSD)病例在30天内的发病率和死亡率转归情况。

研究设计

病例系列研究。

研究地点及时间

2005年12月至2008年12月在拉瓦尔品第的武装部队心脏病学研究所(AFIC/NIHD)。

方法

40例PVR为9.58 + 4.33伍德单位的VSD患者接受双瓣补片闭合术。补片开窗大小为预期主动脉瓣环直径的一半。在开窗的上三分之一上缘附着一块比开窗大5毫米的单独瓣片补片。补片放置时瓣片朝向左心室心尖方向打开。所有病例均采用改良超滤(MUF),术后给予西地那非。

结果

患者年龄为1至28岁,平均年龄为6.66 + 5.70岁。男性22例,女性18例。所有患者术后均尽早停用了血管活性药物和呼吸支持,在重症监护病房(ICU)的停留时间为77.15 + 54.56小时。术后肺动脉压从术前的88.3 + 15.2 mmHg降至42.63 + 10.86 mmHg。术后11例肺动脉压高于体循环且存在血氧饱和度降低的患者发生了肺动脉高压危象,即刻二维超声显示瓣片功能正常且存在右向左分流。40例患者中仅1例早期死亡,总死亡率为2.5%,发病率也较低。

结论

双瓣补片是一种价格低廉、易于构建的技术,对于PVR升高的VSD病例,其发病率和死亡率较低。

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