It has been reported that the center of rotation of each vertebral body is located posterior to the vertebral body center. Moreover, it has been suggested that an optimized follower load (FL) acts posterior to the vertebral body center. However, the optimal position of the FL with respect to typical biomechanical characteristics regarding spinal stabilization, such as joint compressive force, shear force, joint moment, and muscle stress, has not been studied. A variation in the center of rotation of each vertebra was formulated in a three-dimensional finite element model of the lumbar spine with 117 pairs of trunk muscles. Then, the optimal translation of the FL path connecting the centers of rotations was estimated by solving the optimization problem that was to simultaneously minimize the compressive forces, the shear forces, and the joint moments or to minimize the cubic muscle stresses. An upright neutral standing position and a standing position with 200N in both hands were considered. The FL path moved posterior, regardless of the optimization criteria and loading conditions. The FL path moved 5.0 and 7.8mm posterior in upright standing and 4.1mm and 7.0mm posterior in standing with 200N in hands for each optimization scheme. In addition, it was presented that the optimal FL path may have advantages in comparison to the body center FL path. The present techniques may be important in understanding the spine stabilization function of the trunk muscles.