Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Curr Opin Nephrol Hypertens. 2011 May;20(3):258-62. doi: 10.1097/MNH.0b013e32834583ec.
This review discusses the recent evidence that intrinsic glomerular cells including podocytes, parietal epithelial cells and progenitor cells within Bowman's capsule contribute to cellular crescents.
Using a variety of newer molecular markers and lineage tracing experiments, investigators have clearly demonstrated that glomerular cells play a key role in the development and progression of cellular crescents in experimental and human disease.
Crescentic glomerulonephritis is associated with significant morbidity and mortality. Current therapies target the immune system. The recent finding that nonimmune cells also play a role in crescent formation highlights the need to identify alternate and complimentary therapeutic strategies.
本文讨论了近期的证据，即包括足细胞、壁层上皮细胞和鲍曼囊内祖细胞在内的固有肾小球细胞有助于细胞新月体的形成。
研究人员使用各种新型分子标志物和谱系追踪实验，明确证实了肾小球细胞在实验性和人类疾病中细胞新月体的发生和进展中发挥关键作用。
新月体性肾小球肾炎与较高的发病率和死亡率相关。目前的治疗方法针对免疫系统。最近发现非免疫细胞也在新月体形成中起作用，这突出表明需要确定替代和补充的治疗策略。
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