Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Division of Hematology/Oncology, VUMC, 2220 Pierce Avenue, 777 PRB, Nashville, TN 37232-6307, USA.
Breast Cancer Res. 2011 Mar 16;13(2):304. doi: 10.1186/bcr2829.
ERBB receptor tyrosine kinases are activated by ligand-induced dimerization followed by activation and transphosphorylation of their intracellular kinase domains. A recent study by Bill and colleagues demonstrates that receptor transphosphorylation can be regulated from inside the cell by members of the cytohesin protein family. These data highlight a novel mechanism of amplification of ERBB receptor signaling output that may contribute to embryogenesis and cancer progression.
表皮生长因子受体酪氨酸激酶通过配体诱导的二聚化激活,随后其细胞内激酶结构域被激活和转磷酸化。最近,Bill 及其同事的一项研究表明,细胞松弛素蛋白家族成员可以从细胞内调节受体的转磷酸化。这些数据突出了一种新的 ERBB 受体信号输出放大机制,可能有助于胚胎发生和癌症进展。