补充锌对堆型艾美耳球虫诱导的肉鸡氧化损伤的影响

Zinc Supplementation against Eimeria acervulina-Induced Oxidative Damage in Broiler Chickens.

作者信息

Georgieva Nedyalka V, Gabrashanska Margarita, Koinarski Ventsislav, Yaneva Zvezdelina

机构信息

Department of Pharmacology, Animal Physiology and Physiological Chemistry, Faculty of Veterinary Medicine, Trakia University, Student's Campus, 6000 Stara Zagora, Bulgaria.

出版信息

Vet Med Int. 2011 Mar 6;2011:647124. doi: 10.4061/2011/647124.

This study was undertaken to determine the dietary supplements of Zn containing diet on the antioxidant status in chickens experimentally infected with Eimeria acervulina. The antioxidant status was monitored via determination of MDA concentrations and erythrocyte SOD and CAT activities, as well as vitamin E, vitamin C, Cu, and Zn in liver, muscle, and serum. The results showed increased MDA (P < .05), CAT (P < .001), and decreased SOD (P < .001) in the infected birds. Significant changes in Cu and Zn concentrations and dramatically reduction of vitamin C and E concentrations in the infected chickens were found. The observed deviations in the studied enzymes and nonenzymatic parameters evidence the occurrence of oxidative stress following the infection and impaired antioxidant status of chickens, infected with Eimeria acervulina. Our results proved the ameliorating role of CuZn(OH)(3)Cl (0.170 g per kg food) against Eimeria acervulina-induced oxidative damage in infected chickens.

本研究旨在确定含锌日粮对实验感染堆型艾美耳球虫的鸡抗氧化状态的影响。通过测定丙二醛（MDA）浓度、红细胞超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性以及肝脏、肌肉和血清中的维生素E、维生素C、铜和锌来监测抗氧化状态。结果显示，感染鸡的MDA含量增加（P < 0.05），CAT活性增加（P < 0.001），SOD活性降低（P < 0.001）。发现感染鸡的铜和锌浓度有显著变化，维生素C和E浓度大幅降低。所研究的酶和非酶参数的观察偏差证明感染后发生了氧化应激，且感染堆型艾美耳球虫的鸡抗氧化状态受损。我们的结果证明了碱式氯化铜锌（每千克食物0.170克）对感染鸡堆型艾美耳球虫引起的氧化损伤具有改善作用。