来自中国鸡群的两株2型禽副黏病毒的基因组特征分析
Genomic characterization of two avian paramyxovirus type 2 isolates from chickens in China.
作者信息
Li Xiaojiao, Zhang Shouping, Wang Hongwei, Zhao Jixun, Zhang Guozhong
机构信息
Key Laboratory of Zoonosis of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, People's Republic of China.
出版信息
Virus Genes. 2011 Aug;43(1):55-9. doi: 10.1007/s11262-011-0604-x. Epub 2011 Apr 2.
The complete genome sequences were determined for avian paramyxovirus type 2 (APMV-2) strains F8 and NK isolated from chickens in China. Both strains had a genome of 14,904 nucleotides (nt) in length, which followed the "rule of six". Each genome consisted of six genes in the order 3'-N-P-M-F-HN-L-5', with a 55-nt leader at the 3' end and a 154-nt trailer at the 5' end. Sequence alignment and phylogenetic analysis showed that APMV-2 strains F8 and NK shared the highest sequence identity with APMV-2 prototype strain Yucaipa, being classified in the same subgroup as strains Yucaipa, England and Kenya, while strain Bangor represented another subgroup of APMV-2. Among the APMVs, APMV-2 strains F8 and NK exhibited a closer evolutionary relationship with APMV-7 and APMV-8 representative strains.
测定了从中国鸡群中分离出的禽副粘病毒2型（APMV - 2）毒株F8和NK的全基因组序列。两个毒株的基因组长度均为14,904个核苷酸（nt），遵循“六规则”。每个基因组由六个基因组成，顺序为3'-N-P-M-F-HN-L-5'，3'端有一个55 nt的前导序列，5'端有一个154 nt的尾随序列。序列比对和系统发育分析表明，APMV - 2毒株F8和NK与APMV - 2原型毒株尤凯帕具有最高的序列同一性，与尤凯帕、英格兰和肯尼亚毒株归为同一亚组，而班戈毒株代表APMV - 2的另一个亚组。在禽副粘病毒中，APMV - 2毒株F8和NK与APMV - 7和APMV - 8代表毒株表现出更密切的进化关系。
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