伴有骨髓中CD10、末端脱氧核苷酸转移酶及细胞质μ淋巴细胞阳性的儿童暂时性红细胞生成减少症
Transient erythroblastopenia of childhood with CD10, TdT, and cytoplasmic mu lymphocyte positivity in bone marrow.
作者信息
Foot A B, Potter M N, Ropner J E, Wallington T B, Oakhill A
机构信息
Department of Paediatric Oncology, Royal Hospital for Sick Children, Bristol.
出版信息
J Clin Pathol. 1990 Oct;43(10):857-9. doi: 10.1136/jcp.43.10.857.
Over three years, three children presented with anaemia, reticulocytopenia, and marrow erythroblastopenia. A pronounced lymphocytosis was also evident in two of the marrow aspirates, with increased numbers of cells bearing the immunophenotype TdT+, CD10+ HLA DR+, and cytoplasmic mu +, and reported to be compatible with acute lymphoblastic leukaemia (ALL). The clinical course of the illness was fully compatible with transient erythroblastopenia of childhood (TEC), and all three children remained well one to four years after initial presentation. It is concluded that increased numbers of lymphoid cells with a common or pre-B ALL phenotype may be found in bone marrow aspirates of children with TEC, and should not be misdiagnosed as acute leukaemia.
在三年时间里，有三名儿童出现贫血、网织红细胞减少和骨髓成红细胞减少的症状。在两份骨髓穿刺样本中还明显出现了显著的淋巴细胞增多，带有TdT+、CD10+ HLA DR+和细胞质μ+免疫表型的细胞数量增加，据报告这与急性淋巴细胞白血病（ALL）相符。该疾病的临床病程与儿童短暂性成红细胞减少症（TEC）完全相符，所有三名儿童在初次就诊后的一到四年内情况良好。得出的结论是，在患有TEC的儿童骨髓穿刺样本中可能会发现具有常见或前B型ALL表型的淋巴细胞数量增加，不应将其误诊为急性白血病。
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