Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Eur J Pharmacol. 2011 Jun 25;660(2-3):468-75. doi: 10.1016/j.ejphar.2011.03.027. Epub 2011 Apr 2.
Polysorbates are amphiphilic, non-ionic surfactants composed of fatty acid esters of polyoxyethylene sorbitan which are widely used in the cosmetic, food and pharmaceutical industries owing to these special characteristics and their low toxicity profiles. In the present study, polysorbates were investigated for their hypolipidemic activity. C57BL/6J mice and Sprague-Dawley rats were fed a high-fat diet for four weeks, then were divided into several groups, normal saline, polysorbates and positive control drugs such as lovastatin and colestyramine were administered orally to the animals for another four weeks. Complete lipid profiles of the experimental animals were determined by assessing the serum levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. The results indicate that polysorbates significantly lowered the lipid components. Polysorbates are potential candidates for preventing intestinal absorption of redundant lipid from daily intake and subsequently for preventing hyperlipidemia as well as atherosclerosis.
聚山梨酯是一种两亲性非离子表面活性剂，由聚氧乙烯山梨聚糖脂肪酸酯组成，由于其特殊性质和低毒性，广泛应用于化妆品、食品和制药行业。本研究探讨了聚山梨酯的降血脂活性。将 C57BL/6J 小鼠和 Sprague-Dawley 大鼠用高脂肪饮食喂养四周，然后分为几组，给动物口服生理盐水、聚山梨酯和阳性对照药物如洛伐他汀和考来替泊，再喂养四周。通过检测血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平来确定实验动物的完整脂质谱。结果表明，聚山梨酯能显著降低血脂成分。聚山梨酯是预防从日常饮食中吸收多余脂质以及预防高脂血症和动脉粥样硬化的潜在候选药物。
