亨廷顿舞蹈病患者脑脊液中乙酰胆碱酯酶和胆碱的测定
Cerebrospinal fluid acetylcholinesterase and choline measurements in Huntington's disease.
作者信息
Manyam B V, Giacobini E, Colliver J A
机构信息
Department of Medicine, Southern Illinois University School of Medicine, Springfield 62794-9230.
出版信息
J Neurol. 1990 Aug;237(5):281-4. doi: 10.1007/BF00314742.
The caudate nucleus has the highest acetylcholinesterase (AChE) activity in the brain and it has been shown that autopsied brain tissue of patients with Huntington's disease (HD) have reduced levels of acetylcholine. Because of these findings, the cholinergic function in HD was studied by measuring cerebrospinal fluid (CSF) choline levels and AChE activity during a randomized, double-blind, cross-over, placebo-controlled clinical trial of isoniazid. While mean choline levels adjusted for age were lower compared with controls (P = 0.0007), AChE activity did not differ between HD patients and normal controls. Treatment with isoniazid had no significant effect on CSF choline levels or CSF AChE activity. CSF AChE activity showed a statistically significant increase with advancing age. The reduced level of choline in CSF of HD patients may reflect either a defect in choline transport into the brain or a decrease of choline-phospholipid output from the brain.
尾状核在大脑中具有最高的乙酰胆碱酯酶（AChE）活性，并且已经表明，亨廷顿舞蹈病（HD）患者的尸检脑组织中乙酰胆碱水平降低。基于这些发现，在一项关于异烟肼的随机、双盲、交叉、安慰剂对照临床试验中，通过测量脑脊液（CSF）胆碱水平和AChE活性来研究HD中的胆碱能功能。虽然经年龄校正后的平均胆碱水平与对照组相比更低（P = 0.0007），但HD患者和正常对照组之间的AChE活性并无差异。异烟肼治疗对CSF胆碱水平或CSF AChE活性没有显著影响。CSF AChE活性随年龄增长呈现出统计学上的显著增加。HD患者CSF中胆碱水平降低可能反映了胆碱向大脑转运的缺陷，或者大脑中胆碱磷脂输出的减少。
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