Department of Neurology, Bundang CHA Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
Eur Neurol. 2011;65(5):250-6. doi: 10.1159/000324335. Epub 2011 Apr 5.
BACKGROUND/AIMS: It is generally assumed that silent brain infarction (SBI) and symptomatic lacunar infarction (sLAC) share common vascular risk factors and their pathogeneses are known to be similar. However, few studies have conducted a risk factor profile analysis of the two diseases in a single study design.
This study included 64 subjects with SBI lesions, 140 patients with sLAC, and 342 controls by retrospective investigation of brain MRI. Topographic findings and vascular risk factor profiles were compared.
Compared to the controls, the SBI group was found to be associated with hypertension (p = 0.002) and elevated plasma total homocysteine level (p = 0.02). The sLAC group was found to be associated with hypertension (p = 0.001), diabetes (p = 0.004), smoking (p = 0.002), ischemic heart disease (p = 0.01) and hyperlipidemia (p = 0.04). In the present study, risk factor profiles of the SBI and sLAC were not exactly the same, indicating a different pathogenesis between the two diseases.
背景/目的：一般认为，无症状性脑梗死（SBI）和症状性腔隙性梗死（sLAC）具有共同的血管危险因素，其发病机制也相似。然而，很少有研究在单一研究设计中对这两种疾病的危险因素进行分析。
本研究通过回顾性脑 MRI 检查，纳入了 64 例 SBI 病变患者、140 例 sLAC 患者和 342 例对照。比较了两种疾病的影像学发现和血管危险因素谱。
与对照组相比，SBI 组与高血压（p = 0.002）和血浆总同型半胱氨酸水平升高（p = 0.02）相关。sLAC 组与高血压（p = 0.001）、糖尿病（p = 0.004）、吸烟（p = 0.002）、缺血性心脏病（p = 0.01）和高脂血症（p = 0.04）相关。在本研究中，SBI 和 sLAC 的危险因素谱不完全相同，表明这两种疾病的发病机制不同。
