Department of Obstetrics and Gynecology, University of Toyama, 2630, Sugitani, Toyama-shi, Toyama 930-0194, Japan.
Jpn J Clin Oncol. 2011 Jun;41(6):807-10. doi: 10.1093/jjco/hyr041. Epub 2011 Apr 5.
Squamous cell cervical carcinoma that metastasized to the ovary is common in patients with bulky tumors or locally advanced disease; however, ovarian squamous cell carcinoma that metastasized after cervical conization surgery for early microinvasive uterine cervical carcinoma is very rare. We present a case of ovarian squamous cell carcinoma that metastasized 8 years after cervical conization surgery for early microinvasive cervical carcinoma. She had no sign of recurrence in the uterine cervix. We detected human papillomavirus type 16 DNA in both cervical tissue and ovarian tissue, suggesting that ovarian squamous cell carcinoma is derived from microinvasive cervical cancer. Although there are very few cases of early microinvasive squamous cell carcinoma that metastasized to the ovary with delayed recurrence, we should pay attention strictly not only to the cervical condition but also to the ovarian condition on regular post-operative follow-up.
宫颈鳞状细胞癌转移至卵巢在大肿瘤或局部晚期疾病患者中较为常见；然而，宫颈锥形切除术治疗早期微小浸润性宫颈癌后发生的卵巢鳞状细胞癌转移则非常罕见。我们报告了一例宫颈锥形切除术治疗早期微小浸润性宫颈癌 8 年后发生的卵巢鳞状细胞癌转移。她的宫颈无复发迹象。我们在宫颈组织和卵巢组织中均检测到人乳头瘤病毒 16 型 DNA，提示卵巢鳞状细胞癌来源于微小浸润性宫颈癌。尽管早期微小浸润性鳞状细胞癌转移至卵巢且延迟复发的情况非常少见，但我们在定期术后随访中不仅应严格关注宫颈情况，还应关注卵巢情况。
