2-芳基-1,4-萘醌-1-肟甲基醚：它们的细胞毒性活性。

2-Aryl-1,4-naphthoquinone-1-oxime methyl ethers: their cytotoxic activity.

作者信息

Ishikawa Tsutomu, Saito Tatsuru, Kurosawa Ayako, Watanabe Toshiko, Maruyama Sakiko, Ichikawa Yuh-ichiro, Yamada Ryota, Okuzawa Hiroko, Sato Hiromi, Ueno Koichi

机构信息

Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2011;59(4):472-5. doi: 10.1248/cpb.59.472.

DOI:10.1248/cpb.59.472

PMID:21467676

Abstract

Preliminary examination for the structure-activity relationship of quinone monooxime derivatives on cytotoxicity against HeLa S3 cell and further trials using eight different cell lines suggested that 2-aryl-6,7-methylenedioxy-1,4-naphthoquinone-1-oxime methyl ethers, carrying 2-methoxy-4,5-methylenedioxyphenyl, 7-methoxy-2-methylbenzofuran-4-yl, and 2-methoxycarbonyl-3,4-dimethoxyphenyl as the 2-aryl substituent, were potential candidates for anti-cancer drugs.

摘要

对醌单肟衍生物对HeLa S3细胞的细胞毒性进行的构效关系初步研究以及使用八种不同细胞系的进一步试验表明，以2-甲氧基-4,5-亚甲二氧基苯基、7-甲氧基-2-甲基苯并呋喃-4-基和2-甲氧基羰基-3,4-二甲氧基苯基作为2-芳基取代基的2-芳基-6,7-亚甲二氧基-1,4-萘醌-1-肟甲基醚是抗癌药物的潜在候选物。