UDC, Medical Department, A Coruña, Spain.
Cancer Genomics Proteomics. 2011 Mar-Apr;8(2):93-101.
Mutations in signalling pathways essential for embryonic development often lead to tumourigenesis, as is also true for Notch. The aim of this study was to assess the relationship between Notch1 to -4 and their ligands with anatomopathological features of the patients with renal cell carcinoma (RCC).
This study investigated the pattern of protein expression in RCC specimens using tissue microarray technology. A total of 80 paraffin-embedded RCC samples were retrospectively analysed together with ACHN and A.704 cell lines.
Notch1 showed significant positive correlation with chromophobe RCC, no broken capsule, Furhman grade I and when the number of nodes involved was small [(N=1); p=0.039, 0.016, 0.037 and 0.001, respectively)]. Notch3 showed higher expression when the tumour was located in the right kidney (p=0.048).
Notch1 may be useful in the future as a biomarker for the differential diagnosis of different RCC histological subtypes. Notch1 to -3 may also have potential use as a strong prognostic factor.
对于胚胎发育至关重要的信号通路的突变通常会导致肿瘤发生，Notch 也是如此。本研究旨在评估 Notch1 至 -4 及其配体与肾细胞癌 (RCC) 患者的解剖病理学特征之间的关系。
本研究使用组织微阵列技术研究了 RCC 标本中的蛋白表达模式。共分析了 80 例石蜡包埋的 RCC 样本，以及 ACHN 和 A.704 细胞系。
Notch1 与嫌色细胞 RCC、无包膜破裂、Furhman 分级 I 和淋巴结受累数少时呈显著正相关 [(N=1); p=0.039、0.016、0.037 和 0.001]。Notch3 在肿瘤位于右肾时表达更高 (p=0.048)。
Notch1 将来可能有助于鉴别不同 RCC 组织学亚型。Notch1 至 -3 也可能作为一种强有力的预后因素具有潜在的应用价值。
