Bai Y, Liu X M, Guo Z S, Dai W X, Shi Y F, Zhou X Y
Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing.
Chin Med J (Engl). 1990 Sep;103(9):704-8.
We monitored the plasma and urine osmolalities, fractional excretion of sodium, fractional excretion of chloride, plasma levels of antidiuretic hormone (ADH, AVP), aldosterone and atrial natriuretic peptide (ANP) before and after acute water ingestion in 12 patients with overt hypothyroidism. The ability of the patients to dilute and concentrate urine was found impaired and the ability of excretion of water load decreased and delayed. Acute water load test was proved to be effective in evaluating the urinary excreting function for the patients. We hypothesize that inappropriate secretion of anti-diuretic hormone and elevated plasma ANP may be homeostatic factors for abnormal urinary excretion in patients with hypothyroidism.
我们监测了12例显性甲状腺功能减退患者急性饮水前后的血浆和尿渗透压、钠排泄分数、氯排泄分数、抗利尿激素（ADH，AVP）、醛固酮和心房利钠肽（ANP）的血浆水平。发现患者稀释和浓缩尿液的能力受损，水负荷排泄能力下降且延迟。急性水负荷试验被证明对评估患者的尿排泄功能有效。我们推测抗利尿激素分泌不当和血浆ANP升高可能是甲状腺功能减退患者尿排泄异常的稳态因素。
