Stanford Sleep Medicine Center, Redwood City, CA 94063-5704, USA.
Curr Pharm Des. 2011;17(15):1430-5. doi: 10.2174/138161211796197098.
Studies examining GABA(B) receptor agonists have reported effects on sleep including decreased sleep onset latency (SOL), increased sleep consolidation and increases in slow wave sleep (SWS). γ-hydroxybutyrate (GHB) is proposed to act as a GABA(B) receptor agonist; however, the mechanism of action of GHB is controversial. In addition, the GABA(B) receptor agonist, baclofen, has also been proposed to exert similar effects on sleep. The aim of this paper is to provide a review of the human clinical studies of sodium oxybate and baclofen regarding sleep and the treatment of sleep disorders including narcolepsy and insomnia, as well as other disorders involving disrupted sleep such as fibromyalgia.
研究表明，GABA（B）受体激动剂可影响睡眠，包括缩短睡眠潜伏期（SOL）、增加睡眠连续性和增加慢波睡眠（SWS）。γ-羟基丁酸（GHB）被认为是 GABA（B）受体激动剂；然而，GHB 的作用机制存在争议。此外，GABA（B）受体激动剂巴氯芬也被认为对睡眠具有类似的作用。本文旨在综述羟丁酸钠和巴氯芬在人类临床研究中对睡眠的影响，以及对睡眠障碍的治疗作用，包括发作性睡病和失眠症，以及其他涉及睡眠紊乱的疾病，如纤维肌痛。
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