Hirschler Valeria, Meroño Tomas, Maccallini Gustavo, Gomez Rosso Leonardo, Aranda Claudio, Brites Fernando
Durand Hospital, Maipu 812, Buenos Aires, Argentina.
Cardiovasc Hematol Agents Med Chem. 2011 Apr 1;9(2):78-83. doi: 10.2174/187152511796196542.
Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) has been proposed as a biomarker of risk of cardiovascular disease (CVD).
To determine the association between Lp-PLA(2) activity and BMI, insulin-resistance, components of the metabolic syndrome (MS), and lifestyle behaviors in healthy adolescent boys.
Data were collected cross-sectionally from 164 adolescents from an amateur rugby club. BMI, blood pressure (BP), Tanner stages, glucose, insulin, lipids, and Lp-PLA(2) activity were measured. Questionnaires for lifestyle behaviors were completed.
Approximately 26% of the adolescents were obese and 23% overweight. There was a univariate association between Lp-PLA(2) and BMI (r=0.16;p=0.042), triglycerides (r=0.26;p=0.001), LDL-C (r=0.46;p<0.001), apo B (r=0.55;p<0.001), whereas waist circumference , BP, glucose, HOMA-IR, and HDL-C were not correlated. None of the lifestyle behaviors were significantly correlated with Lp-PLA(2). In order to analyze Lp-PLA(2) association with known CVD risk conditions, adolescents were categorized according to overweight/obesity and to the presence of metabolic syndrome. Conversely, as it was for LDL-C and apo B concentration, Lp-PLA(2) activity was not higher in adolescents with obesity. Multiple regression analysis showed that apo B was significantly associated with Lp-PLA(2) adjusted for age, BMI, triglycerides and LDL-C (R2=0.32).
Lp-PLA(2) activity was only associated with apo B adjusted for several confounding variables, suggesting that its clinical utility to identify individuals at risk for CVD does not surpass LDL-C and apo B in healthy adolescents. As plaque morphology may change with age, associations of Lp-PLA(2) with CVD may likewise vary with age.
脂蛋白相关磷脂酶A2（Lp-PLA2）已被提议作为心血管疾病（CVD）风险的生物标志物。
确定健康青春期男孩中Lp-PLA2活性与体重指数（BMI）、胰岛素抵抗、代谢综合征（MS）各组分及生活方式行为之间的关联。
对一个业余橄榄球俱乐部的164名青少年进行横断面数据收集。测量BMI、血压（BP）、坦纳分期、血糖、胰岛素、血脂及Lp-PLA2活性。完成生活方式行为问卷。
约26%的青少年肥胖，23%超重。Lp-PLA2与BMI（r=0.16；p=0.042）、甘油三酯（r=0.26；p=0.001）、低密度脂蛋白胆固醇（LDL-C）（r=0.46；p<0.001）、载脂蛋白B（apo B）（r=0.55；p<0.001）存在单变量关联，而腰围、血压、血糖、稳态模型评估胰岛素抵抗（HOMA-IR）及高密度脂蛋白胆固醇（HDL-C）无相关性。生活方式行为均与Lp-PLA2无显著相关性。为分析Lp-PLA2与已知CVD风险状况的关联，根据超重/肥胖及代谢综合征的存在对青少年进行分类。相反，与LDL-C和apo B浓度情况相同，肥胖青少年的Lp-PLA2活性并不更高。多元回归分析显示，在调整年龄、BMI、甘油三酯和LDL-C后，apo B与Lp-PLA2显著相关（R2=0.32）。
在调整多个混杂变量后，Lp-PLA2活性仅与apo B相关，这表明在健康青少年中，其识别CVD风险个体的临床效用不超过LDL-C和apo B。由于斑块形态可能随年龄变化，Lp-PLA2与CVD的关联可能同样随年龄而异。
