zeste同源物2增强子的高表达表明软组织肉瘤患者预后不良。

High expression of enhancer of zeste homologue 2 indicates poor prognosis in patients with soft tissue sarcomas.

作者信息

Yamaga Kensaku, Osaki Mitsuhiko, Kidani Kazunori, Shomori Kohei, Yoshida Haruhiko, Ito Hisao

机构信息

Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Tottori 683-8503, Japan.

出版信息

Mol Med Rep. 2008 Sep-Oct;1(5):633-9. doi: 10.3892/mmr_00000004.

DOI:10.3892/mmr_00000004

PMID:21479461

Abstract

Enhancer of zeste homologue 2 (EZH2), a member of the polycomb group of genes, is associated with malignancy in several human cancers. The purpose of this study was to examine the association between EZH2 expression and clinicopathological factors as compared to Ki-67 expression in human soft tissue sarcomas. Expression of EZH2 and Ki-67 was immunohistochemically determined in paraffin-embedded sections from 104 soft tissue sarcomas. High expression of both EZH2 and Ki-67 was significantly correlated with distant metastasis (P<0.01), histologic grade (P<0.01) and poor prognosis (P<0.01), but not with clinicopathological factors such as age, sex, and tumor location and size. Although EZH2 expression was significantly correlated with Ki-67 expression (rs=0.65, P<0.01), multivariate analysis showed that high expression of EZH2, but not of Ki-67, was an independent factor of poor prognosis (relative risk = 2.79; P=0.02). These data suggest that expression of EZH2 is a novel and reliable prognostic marker of human soft tissue sarcomas.

摘要

zeste同源物2增强子（EZH2）是多梳基因家族的成员之一，与多种人类癌症的恶性程度相关。本研究的目的是在人类软组织肉瘤中，比较EZH2表达与临床病理因素以及Ki-67表达之间的关联。对104例软组织肉瘤石蜡包埋切片进行免疫组织化学检测，以确定EZH2和Ki-67的表达情况。EZH2和Ki-67的高表达均与远处转移（P<0.01）、组织学分级（P<0.01）和预后不良（P<0.01）显著相关，但与年龄、性别、肿瘤位置和大小等临床病理因素无关。虽然EZH2表达与Ki-67表达显著相关（rs=0.65，P<0.01），但多因素分析显示，EZH2高表达而非Ki-67高表达是预后不良的独立因素（相对风险=2.79；P=0.02）。这些数据表明，EZH2表达是人类软组织肉瘤一种新的、可靠的预后标志物。