接近 HSP90 伴侣-客户关系。
Closing in on the Hsp90 chaperone-client relationship.
机构信息
Center for Integrated Protein Science CIPSM and Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
出版信息
Structure. 2011 Apr 13;19(4):445-6. doi: 10.1016/j.str.2011.03.007.
PMID:21481768
Abstract
The molecular chaperone Hsp90 regulates the activity and stability of a set of client proteins. Despite progress in understanding its mechanism, the interaction of Hsp90 with clients has remained enigmatic. Now, in a recent issue of Molecular Cell, Street and coworkers present results that integrate the client in the Hsp90 chaperone cycle.
摘要
分子伴侣 Hsp90 调节一组客户蛋白的活性和稳定性。尽管在理解其机制方面取得了进展，但 Hsp90 与客户的相互作用仍然是个谜。现在，在最近一期的《Molecular Cell》杂志上，Street 及其同事发表的结果整合了客户蛋白在 Hsp90 伴侣循环中的作用。
Zotero 插件