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[用于治疗股动脉病变的支架的演变]

[Evolution of stents for the treatment of femoral artery lesions].

作者信息

Lejay A, Thaveau F, Bajcz C, Georg Y, Kretz J G, Durand B, Chakfé N

机构信息

Service de Chirurgie Vasculaire, Nouvel Hôpital Civil, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.

出版信息

J Mal Vasc. 2011 Jun;36(3):169-73. doi: 10.1016/j.jmv.2011.03.002. Epub 2011 Apr 8.

Abstract

Endovascular treatment and stent implantation in the superficial femoral artery have been proposed for over 20 years. However, the first experiments with stainless stents were relatively disappointing. The first improvement consisted in the introduction of nitinol self-expanding stents. This technology allowed an initial improvement of clinical performances, but the first generation of nitinol stents demonstrated a relatively high rate of fractures. Better knowledge of the femoral artery biomechanics and advances in technology allowed to propose a second generation of nitinol stents with improved flexibility, which decreased the rates of fracture. In-stent restenosis related to neointimal hyperplasia has also led to the development of new concepts to improve patency rates after stenting of the femoral artery: drug-eluting stents (coated-stents), biodegradable stents, and covered stents. These technologies will help to treat more complex lesions of the femoral artery in the future, with comparable results to those obtained with femoropopliteal bypasses, but we are still waiting for results of ongoing studies.

摘要

股浅动脉的血管内治疗和支架植入术已被提出超过20年。然而,最初使用不锈钢支架的实验结果相对令人失望。首次改进在于引入了镍钛诺自膨胀支架。这项技术使临床性能得到了初步改善,但第一代镍钛诺支架显示出相对较高的骨折发生率。对股动脉生物力学的更深入了解和技术进步使得第二代镍钛诺支架得以问世,其柔韧性得到改善,降低了骨折发生率。与内膜增生相关的支架内再狭窄也促使了新观念的发展,以提高股动脉支架置入后的通畅率:药物洗脱支架(涂层支架)、可生物降解支架和覆膜支架。这些技术将有助于在未来治疗更复杂的股动脉病变,取得与股腘动脉搭桥术相当的效果,但我们仍在等待正在进行的研究结果。

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