Virology Unit, University of Turin, Turin, Italy.
Minerva Med. 2011 Apr;102(2):103-8.
The aim of this study was to report most recent data regarding the occurrence of influenza A virus H1N1v in the lower respiratory tract from a cohort of hospitalized adult patients during the winter season 2009/2010 and investigated the main clinical features and outcomes.
A total of 130 consecutive BAL specimens (collected from October 2009-March 2010) of 101 patients were retrospectively analyzed for influenza A virus H1N1v positivity using a commercial kit.
Overall, 19/130 (14.6%) BAL specimens from 17/101 (16.8%) patients were positive for the novel influenza A H1N1v virus. H1N1v resulted significantly more prevalent in immunocompetent subjects. As regards clinical features, H1N1v resulted more prevalent in respiratory insufficiency or acute respiratory illness. Thirteen patients died during the analytic period; three of them (23.1%) resulted positive to H1N1v but no direct association has been made.
Our cohort study of influenza A H1N1v detection in BAL from hospitalized adult patients confirms the overall moderate clinical impact of this virus, as reported in most reports worldwide. It remains to be evaluated the role of reassortment with influenza virus strains circulating in the winter season 2010/2011 and its potential pathogenicity.
本研究旨在报告 2009/2010 年冬季住院成年患者下呼吸道中甲型 H1N1v 流感病毒的最新发病数据，并调查其主要临床特征和结局。
回顾性分析了 101 例患者共 130 份连续的 BAL 标本（采集自 2009 年 10 月至 2010 年 3 月），使用商业试剂盒检测甲型 H1N1v 流感病毒的阳性率。
130 份 BAL 标本中，共有 19 份（14.6%）来自 17 例（16.8%）患者的标本检测出新型甲型 H1N1v 流感病毒阳性。H1N1v 在免疫功能正常的患者中更为常见。在临床特征方面，H1N1v 在呼吸功能不全或急性呼吸道疾病中更为常见。分析期间有 13 例患者死亡，其中 3 例（23.1%）H1N1v 检测阳性，但未发现直接关联。
本研究通过 BAL 检测住院成年患者中的甲型 H1N1v，证实了该病毒在全球大多数报道中具有中等程度的总体临床影响。仍需评估其与 2010/2011 年冬季流行的流感病毒株重配的作用及其潜在致病性。
