Check J H
Clin Exp Obstet Gynecol. 2011;38(1):5-9.
To describe the diagnosis and treatment of antiphospholipid syndrome as it relates to spontaneous abortion.
The relative importance of performing tests of antiphospholipid antibodies that prolong the partial thromboplastin time and other autoantibodies against phospholipids measured by ELISA are discussed.
The most important diagnostic tests are the lupus anticoagulant, anticardiolipin antibody and antiphosphatidyl serine. Low molecular weight heparin and low dose aspirin are the two most important therapies.
Women with recurrent miscarriages or even an unexplained miscarriage especially after ten weeks (but sometimes even early first trimester) or a history of thrombosis or intrauterine growth restriction and maybe preeclampsia are candidates for anticoagulant therapy, especially with the presence of significant levels of the lupus anticoagulant or anticardiolipin or antiphosphatidyl serine antibodies (> 40 pl units/ml).
描述抗磷脂综合征与自然流产相关的诊断和治疗。
讨论了进行延长部分凝血活酶时间的抗磷脂抗体检测以及通过酶联免疫吸附测定法检测的其他抗磷脂自身抗体的相对重要性。
最重要的诊断检测是狼疮抗凝物、抗心磷脂抗体和抗磷脂酰丝氨酸。低分子量肝素和低剂量阿司匹林是两种最重要的治疗方法。
反复流产甚至原因不明流产的女性，尤其是妊娠十周后（但有时甚至在孕早期），或有血栓形成史、宫内生长受限史以及可能有先兆子痫史的女性，尤其是存在高水平狼疮抗凝物、抗心磷脂或抗磷脂酰丝氨酸抗体（>40磷脂单位/毫升）时，是抗凝治疗的候选对象。
Zotero 插件