Conca Andreas, Di Pauli Jan, Hinterhuber Hartmann, Kapfhammer Hans-Peter
Psychiatrischer Dienst des Gesundheitsbezirkes Bozen-Suditrol.
Neuropsychiatr. 2011;25(1):1-8.
Recently Deep brain stimulation (DBS) has found continuous use in treatment of neurological movement disorders. However DBS in psychiatric illnesses is less investigated. Its application in depression, obsessive-compulsive disorder, and therapy-resistant Tourette- Syndrome shows positive effects and offers an advanced alternative to neurosurgical therapies of the past. There are also case reports suggesting therapeutic benefits in schizophrenia and addiction. To a large extent, the mechanisms of action appear to be still unknown; the side effects seem partially modulated through the stimulation parameters. Furthermore, some ethics committees argue that DBS exhibits a relevant impact on the personality. The novel approach as well as the unknown long term effects of DBS implicate that the technique can be performed only under strict individual diagnosis and rigorous consideration of all ethical concerns.
最近，深部脑刺激（DBS）已被持续用于治疗神经运动障碍。然而，DBS在精神疾病中的研究较少。其在抑郁症、强迫症和难治性抽动秽语综合征中的应用显示出积极效果，并为过去的神经外科治疗提供了一种先进的替代方法。也有病例报告表明其对精神分裂症和成瘾有治疗益处。在很大程度上，其作用机制似乎仍然未知；副作用似乎部分通过刺激参数来调节。此外，一些伦理委员会认为DBS对人格有显著影响。DBS的新方法以及未知的长期影响意味着该技术只能在严格的个体诊断和对所有伦理问题进行严格考虑的情况下进行。
