75岁以上供体肝脏移植的结果：病例对照研究。

Results of liver transplantation from donors over 75 years: case control study.

作者信息

Cascales Campos P, Ramírez P, Gonzalez R, Domingo J, Martínez Frutos I, Sánchez Bueno F, Robles R, Miras M, Pons J A, Parrilla P

机构信息

Department of Surgery, Liver Transplant Unit, Virgen de la Arrixaca University Hospital, Murcia, Spain.

出版信息

Transplant Proc. 2011 Apr;43(3):683-6. doi: 10.1016/j.transproceed.2011.01.087.

DOI:10.1016/j.transproceed.2011.01.087

PMID:21486573

Abstract

INTRODUCTION

The use of elderly donors can increase the pool of organs available for transplant. The aim of this study was to analyze the outcomes of grafts from donors older than 75 years.

PATIENTS AND METHODS

We selected 29 patients transplanted from January 2003 to January 2010 with livers from donors older than 75 years for comparison with a control group (58 patients), selected among patients transplanted immediately before or after each study case. Data analyzed using SPSS 15.0 were considered statistically significant at P < .05.

RESULTS

Statistically significant differences were evident in the mean age of donors (78.3 ± 2.9 vs 50.4 ± 17.8 years, P < .001), levels of aspartate aminotransferase alanine aminotransferase (30.8 ± 18.13/24.9 ± 14.4 vs 53.81 ± 68.4/39.37 ± 39.94 U/L, P < .05), and waiting list time of (122.4 ± 94.3 vs 169.2 ± 135.5 days, P = .034) of elderly donor versus control graft cohorts. The median follow-up was 32 months (range: 4-88.0) No differences were observed at 1 and 3 years after transplantation: graft survival was 78% and 61% in the older donor group and 83% and 71% in the younger donor group, respectively.

CONCLUSION

The use of expanded donors from elderly subjects can increase the donor pool with good results.

摘要

引言

使用老年供体可增加可供移植的器官库。本研究旨在分析来自75岁以上供体的移植物的转归情况。

患者与方法

我们选取了2003年1月至2010年1月间接受75岁以上供体肝脏移植的29例患者，并与对照组（58例患者）进行比较，对照组在每个研究病例前后立即进行移植的患者中选取。使用SPSS 15.0分析的数据在P < 0.05时被认为具有统计学意义。

结果

老年供体与对照移植物队列在供体平均年龄（78.3 ± 2.9岁对50.4 ± 17.8岁，P < 0.001）、天冬氨酸转氨酶和丙氨酸转氨酶水平（30.8 ± 18.13/24.9 ± 14.4对53.81 ± 68.4/39.37 ± 39.94 U/L，P < 0.05）以及等待名单时间（122.4 ± 94.3对169.2 ± 135.5天，P = 0.034）方面存在明显的统计学差异。中位随访时间为32个月（范围：4 - 88.0个月）。移植后1年和3年未观察到差异：老年供体组的移植物存活率分别为78%和61%，年轻供体组分别为83%和71%。