Centre for Health Informatics, Australian Institute of Health Innovation, University of New South Wales, Sydney, Australia.
J Am Med Inform Assoc. 2011 May 1;18(3):259-66. doi: 10.1136/amiajnl-2010-000075.
To model how individual violations in routine clinical processes cumulatively contribute to the risk of adverse events in hospital using an agent-based simulation framework.
An agent-based simulation was designed to model the cascade of common violations that contribute to the risk of adverse events in routine clinical processes. Clinicians and the information systems that support them were represented as a group of interacting agents using data from direct observations. The model was calibrated using data from 101 patient transfers observed in a hospital and results were validated for one of two scenarios (a misidentification scenario and an infection control scenario). Repeated simulations using the calibrated model were undertaken to create a distribution of possible process outcomes. The likelihood of end-of-chain risk is the main outcome measure, reported for each of the two scenarios.
The simulations demonstrate end-of-chain risks of 8% and 24% for the misidentification and infection control scenarios, respectively. Over 95% of the simulations in both scenarios are unique, indicating that the in-patient transfer process diverges from prescribed work practices in a variety of ways.
The simulation allowed us to model the risk of adverse events in a clinical process, by generating the variety of possible work subject to violations, a novel prospective risk analysis method. The in-patient transfer process has a high proportion of unique trajectories, implying that risk mitigation may benefit from focusing on reducing complexity rather than augmenting the process with further rule-based protocols.
使用基于代理的仿真框架,构建模型以了解常规临床流程中的个体违规行为如何累积导致医院不良事件的风险。
设计了基于代理的仿真模型,以模拟导致常规临床流程中不良事件风险的常见违规行为的级联。临床医生及其支持的信息系统使用直接观察到的数据,代表为一组相互作用的代理。该模型使用在一家医院观察到的 101 例患者转科数据进行校准,结果针对两种情况(身份识别错误和感染控制情况)之一进行了验证。使用经过校准的模型进行了多次重复模拟,以创建可能的流程结果分布。主要结果测量是末端风险的可能性,为两种情况中的每一种报告。
模拟结果表明,身份识别错误和感染控制情况下的末端风险分别为 8%和 24%。在这两种情况下,超过 95%的模拟都是独特的,这表明住院患者的转科流程在多种方面偏离了既定的工作实践。
该仿真模型通过生成各种可能的违规工作,为临床流程中的不良事件风险建模,提供了一种新颖的前瞻性风险分析方法。住院患者的转科流程有很高比例的独特轨迹,这意味着风险缓解可能受益于减少复杂性,而不是通过进一步基于规则的协议来增强流程。