异构性心脏蛋白酶体：由不同的底物决定？
Heterogeneous cardiac proteasomes: mandated by diverse substrates?
机构信息
Departments of Physiology and Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
出版信息
Physiology (Bethesda). 2011 Apr;26(2):106-14. doi: 10.1152/physiol.00039.2010.
PMID:21487029
Abstract
Proteasome biology has taken central stage in cardiac physiology and pathophysiology. The molecular heterogeneity of proteasome subpopulations supports the specificity of proteasome function to degrade diverse substrate repertoires. Unveiling the dynamics of proteasome function should inspire new therapeutic strategies for combating cardiac disease.
摘要
蛋白酶体生物学在心脏生理学和病理生理学中占据核心地位。蛋白酶体亚群的分子异质性支持蛋白酶体功能的特异性，以降解不同的底物谱。揭示蛋白酶体功能的动态变化应该为对抗心脏疾病的新治疗策略提供启示。
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