Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjukuku, Tokyo, 160-0023, Japan.
Odontology. 2011 Jul;99(2):203-8. doi: 10.1007/s10266-011-0001-x. Epub 2011 Apr 13.
Malignant fibrous histiocytoma (MFH) originates from primitive mesenchymal cells and has the capacity for dual histiocytic and fibroblastic differentiation. We report on an MFH of the left maxilla that developed in a 79-year old woman 20 years after surgery and radiation for squamous cell carcinoma (SCC). Postoperative radiotherapy with 70 Gy was administered for a primary neoplasm of SCC of the left maxilla to a localized field through two lateral ports. This secondary neoplasm arose at the site of tumor resection (partial maxillectomy) within the irradiated field, and was resected. The development of sarcomas is a recognized complication of radiation therapy. The final diagnosis after the operation was MFH. The patient died of tumor recurrence at the skull base and within the cranium, 19 months after the operation. Radiation-induced sarcoma is well known, but radiation-induced MFH is relatively rare in the head and neck region. The details of this case are presented with a review of literature.
恶性纤维组织细胞瘤（MFH）来源于原始间充质细胞，具有双相组织细胞和成纤维细胞分化的能力。我们报告了一例发生于左上颌的 MFH，患者为 79 岁女性，20 年前因鳞状细胞癌（SCC）接受了手术和放疗。为了治疗左侧上颌的 SCC 原发性肿瘤，通过两个外侧端口在局部区域给予了 70 Gy 的术后放疗。这个继发性肿瘤发生在照射野内肿瘤切除部位（上颌部分切除术），并进行了切除。肉瘤的发生是放射治疗的一种公认的并发症。手术后的最终诊断是 MFH。患者在手术后 19 个月因颅骨底部和颅内肿瘤复发而死亡。放射诱导性肉瘤是众所周知的，但在头颈部，放射诱导性 MFH 相对较少见。本文结合文献复习报道了该病例的详细情况。
