Department of Obstetrics and Gynecology, Medical University of Lublin, Staszica 16 Street, 20-081 Lublin, Poland.
Oncol Rep. 2011 Jul;26(1):153-60. doi: 10.3892/or.2011.1256. Epub 2011 Apr 12.
Human papillomavirus (HPV) is widely accepted as the main cause of cervical cancer. However, the presence of HPV DNA does not inescapably lead to the development of the cancerous phenotype of the infected cell. Therefore, it is considered that the induction of full cancerous expression of HPV requires additional cofactors. The aim of this study was to assess the expression of estrogen receptor α (ERα) and progesterone receptor (PR) in archived tissue blocks of squamous cell carcinoma and adenocarcinoma of the uterine cervix and to ascertain whether expression of these receptors is associated with the presence of HPV DNA. The investigation was performed using formalin-fixed, paraffin-embedded cervical cancer specimens obtained from 250 women who underwent surgery for histologically confirmed neoplastic lesions. The control group consisted of normal cervical tissues obtained from 50 patients who underwent myomectomy. The results of this study revealed that the expression of ER and PR in planoepithelial cancers and adenocarcinomas of the cervix were decreased to undetectable levels. Only in singular cases in the pattern of staining the expression of ER and PR was noted. In stromal cells of the tested neoplasms, higher expression of both types of receptors was found. Comparison of the expression of ER and PR in the staining pattern and stroma of both squamous cell carcinoma and adenocarcioma of the cervix, showed statistically higher expression in the stromal cells. Strong expression (+1, +2, +3) of ER and PR was noted in the stromal cells irrespective of HPV infection, histopathological type of cancer, and clinical and histopathological grade.
人乳头瘤病毒（HPV）被广泛认为是宫颈癌的主要病因。然而，HPV DNA 的存在并不能必然导致感染细胞发生癌变。因此，人们认为 HPV 的完全癌变表达需要额外的协同因子。本研究旨在评估雌激素受体 α（ERα）和孕激素受体（PR）在子宫颈鳞癌和腺癌存档组织块中的表达，并确定这些受体的表达是否与 HPV DNA 的存在相关。使用从 250 名接受手术治疗的经组织学证实患有肿瘤性病变的女性中获得的福尔马林固定、石蜡包埋的宫颈癌标本进行了该研究。对照组由 50 名接受子宫肌瘤切除术的患者的正常宫颈组织组成。该研究的结果表明，在扁平上皮癌和宫颈癌腺癌中，ER 和 PR 的表达降低至无法检测的水平。仅在个别病例中观察到 ER 和 PR 的表达呈染色模式。在测试的肿瘤间质细胞中，两种受体的表达均较高。比较宫颈癌鳞癌和腺癌的染色模式和基质中 ER 和 PR 的表达，发现基质细胞中的表达具有统计学意义。无论 HPV 感染、癌症的组织病理学类型以及临床和组织病理学分级如何，在间质细胞中均观察到 ER 和 PR 的强表达（+1、+2、+3）。
