Savoiu Germaine, Drăgan Simona, Cristescu Carmen, Serban Corina, Noveanus Lavinia, Ionescu Daniela, Nicola T, Duicu Oana, Raducan Andreea, Voicu Mirela
Anatomy, Physiology and Pathophysiology Department, School of Pharmacy, University of Medicine and Pharmacy V. Babeş Timişoara.
Rev Med Chir Soc Med Nat Iasi. 2009 Apr-Jun;113(2):397-401.
Oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Increased wall thickness precedes plaque formation and noninvasive B-mode ultrasonographic measurement of IMT is considered a useful marker of the development of the carotid atherosclerosis.
The present study was designed to assess the association of oxidized low-density lipoprotein (ox-LDL) with carotid intima-media thickness (IMT) in hypertensive patients. Oxidized LDL (enzyme-linked immunosorbent assay, Elisa) and carotid IMT (high-resolution B-mode ultrasonography) were assessed in 74 patients, aged between 45 and 65 years, diagnosticated with arterial hypertension.
We observed significantly higher plasma levels of total cholesterol (236.32 +/- 41.96 mg/dl), LDL cholesterol (166.92 +/- 38.55 mg/dl), triglycerides (180.79 +/- 72.05 mg/dl) and low plasma levels of HDL-cholesterol (33.24 +/- 7.99 mg/dl) in all patients. We noticed higher plasma levels of ox-LDL (77.34 +/- 24.78 mg/dl) and carotid IMT was increased (1.41 +/- 0.31 mm). The statistically analysis done using Pearson's test and Student's t - test indicated that there were correlations of ox-LDL with: IMT (p < 0.05, r = 0.408), total cholesterol (p < 0.05, r = 0.498), LDL-cholesterol (p < 0.05, r = 0.527), triglycerides (p < 0.05, r = 0.385) and HDL-cholesterol (p < 0.05, r = -0.442).
Higher plasma levels of ox-LDL were associated with increased carotid IMT in hypertensive patients. Measurement of plasma Ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions.
低密度脂蛋白（LDL）的氧化在动脉粥样硬化的发病机制中起重要作用。在斑块形成之前，血管壁厚度会增加，而采用B型超声对内膜中层厚度（IMT）进行无创测量被认为是颈动脉粥样硬化发展的一个有用指标。
本研究旨在评估高血压患者中氧化型低密度脂蛋白（ox-LDL）与颈动脉内膜中层厚度（IMT）之间的关联。对74例年龄在45至65岁之间、被诊断为动脉高血压的患者进行了氧化型LDL（酶联免疫吸附测定，ELISA法）和颈动脉IMT（高分辨率B型超声检查）的评估。
我们观察到所有患者的血浆总胆固醇水平（236.32±41.96mg/dl）、低密度脂蛋白胆固醇水平（166.92±38.55mg/dl）、甘油三酯水平（180.79±72.05mg/dl）显著升高，而高密度脂蛋白胆固醇水平（33.24±7.99mg/dl）较低。我们注意到氧化型LDL的血浆水平较高（77.34±24.78mg/dl），且颈动脉IMT增加（1.41±0.31mm）。使用Pearson检验和Student's t检验进行的统计学分析表明，氧化型LDL与以下指标存在相关性：IMT（p<0.05，r=0.408）、总胆固醇（p<0.05，r=0.498）、低密度脂蛋白胆固醇（p<0.05，r=0.527）、甘油三酯（p<0.05，r=0.385）和高密度脂蛋白胆固醇（p<0.05，r=-0.442）。
高血压患者血浆氧化型LDL水平升高与颈动脉IMT增加有关。血浆氧化型LDL和颈动脉IMT的测量可能是动脉粥样硬化的有用指标，也可能是治疗干预的潜在靶点。
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