韩国人群 Toll 样受体 2 基因多态性：与慢性鼻-鼻窦炎的相关性。

Toll-like receptor 2 gene polymorphisms in a Korean population: association with chronic rhinosinusitis.

机构信息

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Korea, Seoul, Korea.

出版信息

Otolaryngol Head Neck Surg. 2011 Jan;144(1):96-100. doi: 10.1177/0194599810390881.

DOI:10.1177/0194599810390881

PMID:21493395

Abstract

OBJECTIVE

To investigate the role of single-nucleotide polymorphisms (SNPs) in the gene encoding Toll-like receptor (TLR) 2 in Korean patients with chronic rhinosinusitis (CRS) and controls.

STUDY DESIGN AND SETTING

A case-control study.

SUBJECTS AND METHODS

Subjects (N = 214) were all adults (>20 years old) and were divided into patients with CRS (n = 106) and controls (n = 108). Five SNPs (rs1898830, rs3804099, rs3804100, R677W, and rs5743708) were selected and genotyped in a case-control study with the single-base-pair primer extension (SNaPshot) assay.

RESULTS

The case-control study revealed that 2 SNPs in TLR2, rs3804099 (odds ratio [OR] = 2.88; 95% confidence interval [CI] = 1.17-7.09; P = .022) and rs3804100 (OR = 3.76; 95% CI = 1.42-9.96; P = .008), showed significant differences in minor allele frequency between CRS patients and controls. These 2 SNPs were correlated with CRS risk in Korean patients.

CONCLUSIONS

Two SNPs in TLR2 may be associated with increased risk of CRS in Korean subjects.

摘要

目的

探讨 Toll 样受体（TLR）2 基因单核苷酸多态性（SNP）在韩国慢性鼻-鼻窦炎（CRS）患者和对照者中的作用。

研究设计和设置

病例对照研究。

受试者和方法

受试者（N=214）均为成年人（>20 岁），分为 CRS 患者（n=106）和对照组（n=108）。在一项病例对照研究中，选择并通过单碱基引物延伸（SNaPshot）检测 TLR2 中的 5 个 SNP（rs1898830、rs3804099、rs3804100、R677W 和 rs5743708）进行基因分型。

结果

病例对照研究显示，TLR2 中的 2 个 SNP（rs3804099，OR=2.88；95%置信区间[CI]：1.17-7.09；P=0.022）和 rs3804100（OR=3.76；95%CI：1.42-9.96；P=0.008）在 CRS 患者和对照组之间的次要等位基因频率存在显著差异。这 2 个 SNP 与韩国患者 CRS 风险相关。