Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Catholic University of Korea, Seoul, Korea.
Otolaryngol Head Neck Surg. 2011 Jan;144(1):96-100. doi: 10.1177/0194599810390881.
To investigate the role of single-nucleotide polymorphisms (SNPs) in the gene encoding Toll-like receptor (TLR) 2 in Korean patients with chronic rhinosinusitis (CRS) and controls.
A case-control study.
Subjects (N = 214) were all adults (>20 years old) and were divided into patients with CRS (n = 106) and controls (n = 108). Five SNPs (rs1898830, rs3804099, rs3804100, R677W, and rs5743708) were selected and genotyped in a case-control study with the single-base-pair primer extension (SNaPshot) assay.
The case-control study revealed that 2 SNPs in TLR2, rs3804099 (odds ratio [OR] = 2.88; 95% confidence interval [CI] = 1.17-7.09; P = .022) and rs3804100 (OR = 3.76; 95% CI = 1.42-9.96; P = .008), showed significant differences in minor allele frequency between CRS patients and controls. These 2 SNPs were correlated with CRS risk in Korean patients.
Two SNPs in TLR2 may be associated with increased risk of CRS in Korean subjects.
探讨 Toll 样受体（TLR）2 基因单核苷酸多态性（SNP）在韩国慢性鼻-鼻窦炎（CRS）患者和对照者中的作用。
病例对照研究。
受试者（N=214）均为成年人（>20 岁），分为 CRS 患者（n=106）和对照组（n=108）。在一项病例对照研究中，选择并通过单碱基引物延伸（SNaPshot）检测 TLR2 中的 5 个 SNP（rs1898830、rs3804099、rs3804100、R677W 和 rs5743708）进行基因分型。
病例对照研究显示，TLR2 中的 2 个 SNP（rs3804099，OR=2.88；95%置信区间[CI]：1.17-7.09；P=0.022）和 rs3804100（OR=3.76；95%CI：1.42-9.96；P=0.008）在 CRS 患者和对照组之间的次要等位基因频率存在显著差异。这 2 个 SNP 与韩国患者 CRS 风险相关。
TLR2 中的 2 个 SNP 可能与韩国人群 CRS 风险增加相关。
