CHITTARANJAN ANDRADE, M.D., Additional Professor, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore - 560 029.
Indian J Psychiatry. 1998 Jul;40(3):240-6.
There is little published research in mainstream Indian journals of the clinical psychotropic properties of herbal medicines. The present study therefore evaluated the psychotropic effects of Memorin (from a pharmaceutical house based at Maharashtra), a herbal formulation. Subjects with DSM-IV age-related cognitive decline were randomized to receive Memorin (n=22) or placebo (n=23) for three months. Before and after treatment, all subjects completed a battery of neuropsychological tests that assessed visual and verbal memory, visuospatial skills, and perceptuomotor functioning Subjects and rater were alike blind to treatment group. The results revealed that in the Memorin group, on most tests significant improvement in performances were observed after treatment; improvement in many of the memory tasks was however confined to males; age did not significantly influence the results. In contrast, in placebo-treated subjects there was little therapeutic gain. It is concluded that irrespective of the subject's actual age, Memorin may benefit elderly persons, particularly males, who experience age-related cognitive decline.
印度主流医学期刊上鲜有草药精神治疗特性的研究。因此，本研究评估了 Memorin（来自马哈拉施特拉邦的制药公司）的精神治疗效果。该草药配方用于年龄相关性认知衰退的受试者。受试者随机分为 Memorin 组（n=22）和安慰剂组（n=23），接受为期三个月的治疗。治疗前后，所有受试者均完成了一系列神经心理测试，评估视觉和语言记忆、视空间技能和知觉运动功能。受试者和评估者对治疗组均不知情。结果显示，在 Memorin 组，治疗后大多数测试的表现均显著改善；然而，许多记忆任务的改善仅限于男性；年龄对结果无显著影响。相比之下，安慰剂治疗组的治疗效果甚微。结论是，无论受试者的实际年龄如何，Memorin 可能有益于年龄相关性认知衰退的老年人，尤其是男性。
