Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Gunma, Japan.
Int J Eat Disord. 2012 Apr;45(3):447-9. doi: 10.1002/eat.20927. Epub 2011 Apr 14.
We report the case of an anorexia nervosa (AN) patient with extremely low body weight who became pregnant following ovulation induction and subsequently delivered an infant with micropolygyria. To the best of our knowledge, no previous report has described live birth for a patient with such low body weight. The patient underwent hMG-hCG therapy for ovulation induction. Despite becoming pregnant, weight loss continued with extreme anemia occurring during the pregnancy. However, blood transfusion therapy was used for successful treatment. Despite the therapeutic and protective measures instituted, the child was born with micropolygyria. Pregnancy in an AN patient with extremely low body weight needs therapeutic intervention during early pregnancy with aggressive precautionary measures, particularly against anemia. On the basis of our experience, we consider that ovulation induction therapy should not be administered without sufficient caution for an AN patient with low body weight.
我们报告了一例神经性厌食症(AN)极低体重患者,该患者在诱导排卵后怀孕,并随后生下了一名患有微脑回畸形的婴儿。据我们所知,以前没有报道过如此低体重的患者有活产。患者接受 hMG-hCG 疗法诱导排卵。尽管怀孕了,但体重仍继续下降,怀孕期间出现严重贫血。然而,采用输血疗法进行了成功治疗。尽管采取了治疗和保护措施,但孩子还是出生时患有微脑回畸形。对于极低体重的 AN 患者,妊娠需要在早孕期间进行治疗干预,并采取积极的预防措施,特别是针对贫血。根据我们的经验,我们认为对于体重低的 AN 患者,不应在没有充分谨慎的情况下进行排卵诱导治疗。