College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
J Endod. 2011 May;37(5):667-72. doi: 10.1016/j.joen.2011.02.003.
This study evaluated the formation of reparative hard tissues in baboon pulps after Emdogain (EMD) application in conjunction with 3 pulp-capping materials.
Thirty-two premolars in four 3-year-old baboons were randomly assigned to 1 of 3 pulp-capping materials. A split-mouth design and intra-animal side randomization were applied to 3 experimental groups (calcium hydroxide, ProRoot White mineral trioxide aggregate, white Portland cement) and the control group (no pulp-capping material). In the hybrid EMD approach, a small drop of EMD was placed over the exposure site after arrest of hemorrhage. The designated pulp-capping material was placed over the EMD, followed by placement of resin-modified glass ionomer cement over the set/unset pulp-capping material. The animals were killed after 4 months. Histomorphometric analysis and micro-computed tomography were performed on the retrieved specimens.
All groups capped with EMD and 1 of the 3 capping materials exhibited similar reparative tissue thickness (P > .05). Dentin tunnel defects were absent in the mineral trioxide aggregate and Portland cement groups after the use of EMD. However, only a tubular was identified from all specimens.
Mineral trioxide aggregate produces a better quality reparative hard tissue response with the adjunctive use of Emdogain, when compared with the use of calcium hydroxide.
本研究评估了 Emdogain（EMD）联合 3 种盖髓材料应用于狒狒牙髓后修复性硬组织的形成。
将 32 颗 3 岁狒狒的前磨牙随机分为 3 种盖髓材料的 1 组。采用分口设计和动物内侧随机化，将 3 个实验组（氢氧化钙、ProRoot White 矿化三氧化物凝聚体、白色波特兰水泥）和对照组（无盖髓材料）。在混合 EMD 方法中，在出血停止后，在暴露部位放置一小滴 EMD。将指定的盖髓材料放置在 EMD 上，然后将树脂改性玻璃离子水门汀放置在凝固/未凝固的盖髓材料上。4 个月后处死动物。对取出的标本进行组织形态计量学分析和微计算机断层扫描。
所有用 EMD 和 3 种盖髓材料中的 1 种盖髓的组，修复性组织厚度相似（P >.05）。在使用 EMD 后，矿化三氧化物凝聚体和波特兰水泥组均未出现牙本质隧道缺陷。然而，仅从所有标本中识别出一个管腔。
与使用氢氧化钙相比，矿物三氧化物聚合体在使用 Emdogain 时产生更好质量的修复性硬组织反应。
