RIG-I 对病毒核酸的感应：从易位到翻译。
Sensing of viral nucleic acids by RIG-I: from translocation to translation.
机构信息
Division of Clinical Pharmacology, Ludwig-Maximilian University Munich, Munich, Germany.
出版信息
Eur J Cell Biol. 2012 Jan;91(1):78-85. doi: 10.1016/j.ejcb.2011.01.015. Epub 2011 Apr 14.
Abstract
The innate immune system is a first layer of defense against infection by pathogens. It responds to pathogens by activating host defense mechanisms via interferon and inflammatory cytokine expression. Pathogen associated molecular patterns (PAMPs) are sensed by specific pattern recognition receptors. Among those, the ATP dependent helicase related RIG-I like receptors RIG-I, MDA5 and LGP2 sense the presence of viral RNA in the cytoplasm of host cells. While the precise PAMPs and functions of MDA5 or LGP2 are still unclear, RIG-I senses predominantly viral RNA containing a 5'-triphosphate along with dsRNA regions. Here we review our current knowledge of how these PAMPs are sensed and integrated by RIG-I, and how RIG-I's innate immune function can be used in translational medical approaches.
摘要
先天免疫系统是抵御病原体感染的第一道防线。它通过干扰素和炎症细胞因子的表达来激活宿主防御机制，从而对病原体做出反应。病原体相关分子模式（PAMPs）被特定的模式识别受体感知。其中，ATP 依赖性解旋酶相关的 RIG-I 样受体 RIG-I、MDA5 和 LGP2 感知宿主细胞细胞质中病毒 RNA 的存在。虽然 MDA5 或 LGP2 的精确 PAMPs 和功能仍不清楚，但 RIG-I 主要感知含有 5'-三磷酸和 dsRNA 区域的病毒 RNA。在这里，我们回顾了我们目前对这些 PAMPs 如何被 RIG-I 感知和整合的认识，以及 RIG-I 的先天免疫功能如何在转化医学方法中得到应用。
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