源自胚胎16三体小鼠的海马移植体表现出淀粉样蛋白（A4）和神经原纤维病变。 - Suppr | 超能文献

Hippocampal grafts derived from embryonic trisomy 16 mice exhibit amyloid (A4) and neurofibrillary pathology.

作者信息

Richards S J, Waters J J, Rogers D C, Martel F L, Sparkman D R, White C L, Beyreuther K, Masters C L, Dunnett S B

机构信息

MRC Molecular Genetics Unit, Addenbrooke's Hospital, Cambridge, England, UK.

出版信息

Prog Brain Res. 1990;82:215-23. doi: 10.1016/s0079-6123(08)62607-2.

DOI:10.1016/s0079-6123(08)62607-2

Abstract

摘要

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1

Hippocampal grafts derived from embryonic trisomy 16 mice exhibit amyloid (A4) and neurofibrillary pathology.源自胚胎16三体小鼠的海马移植体表现出淀粉样蛋白（A4）和神经原纤维病变。

Prog Brain Res. 1990;82:215-23. doi: 10.1016/s0079-6123(08)62607-2.

2

Ultrastructural neuropathology in murine trisomy 16 hippocampal grafts.

Neuroreport. 1993 Feb;4(2):208-10. doi: 10.1097/00001756-199302000-00024.

3

Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology.小鼠16号染色体三体海马移植提供了一种阿尔茨海默病神经病理学模型。

EMBO J. 1991 Feb;10(2):297-303. doi: 10.1002/j.1460-2075.1991.tb07950.x.

4

Long-term intracerebral transplants of fetal hippocampus from mouse trisomy 16, a model for Down's syndrome (trisomy 21), do not exhibit Alzheimer's disease neuropathology by ultrastructural criteria .来自16三体小鼠（唐氏综合征（21三体）模型）的胎儿海马体的长期脑内移植，根据超微结构标准，未表现出阿尔茨海默病神经病理学特征。

Tissue Cell. 1994 Aug;26(4):477-88. doi: 10.1016/0040-8166(94)90001-9.

5

Long-term transplants of mouse trisomy 16 hippocampal neurons, a model for Down's syndrome, do not develop Alzheimer's disease neuropathology.唐氏综合征模型——小鼠16号染色体三体海马神经元的长期移植不会发展为阿尔茨海默病神经病理学。

Brain Res. 1993 May 7;610(2):295-304. doi: 10.1016/0006-8993(93)91413-m.

6

Long-term basal forebrain cholinergic-rich grafts derived from trisomy 16 mice do not develop beta-amyloid pathology and neurodegeneration but demonstrate neuroinflammatory responses.源自16三体小鼠的长期富含基底前脑胆碱能的移植物不会出现β-淀粉样蛋白病理和神经退行性变，但会表现出神经炎症反应。

Int J Dev Neurosci. 1998 Nov-Dec;16(7-8):763-75. doi: 10.1016/s0736-5748(98)00085-9.

7

[Can the neurotransplants of mice with chromosome 16 trisomy be considered as a model of pathological changes typical for Alzheimer disease?].[16号染色体三体小鼠的神经移植能否被视为阿尔茨海默病典型病理变化的模型？]

Biull Eksp Biol Med. 1999 Nov;128(11):559-64.

8

The neuropathology of Alzheimer's disease investigated by transplantation of mouse trisomy 16 hippocampal tissues.通过移植小鼠16三体海马组织研究阿尔茨海默病的神经病理学。

Trends Neurosci. 1991 Aug;14(8):334-8. doi: 10.1016/0166-2236(91)90157-p.

9

Transplantation of cryopreserved fetal hippocampal cells into ischemic lesions in the adult rat hippocampus.将冷冻保存的胎鼠海马细胞移植到成年大鼠海马的缺血性损伤部位。

Cell Transplant. 1994;3 Suppl 1:S39-41. doi: 10.1177/096368979400301s15.

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Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.神经退行性变的小鼠模型：16三体移植中基底前脑胆碱能神经元萎缩

Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1383-7. doi: 10.1073/pnas.89.4.1383.

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Transgenic animals as models for human disease--report of an EC Study Group.作为人类疾病模型的转基因动物——欧洲共同体研究小组报告

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Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged.阿尔茨海默病患者、关岛帕金森病-痴呆综合征患者、老年痴呆患者以及老年人海马中组织蛋白酶蛋白酶和内源性抑制剂（胱抑素）的异常分布。

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