英夫利昔单抗治疗药物难治性神经结节病。

Medically refractory neurosarcoidosis treated with infliximab.

机构信息

Department of Medicine, University of Auckland Department of Neurology, Auckland City Hospital, Auckland, New Zealand.

出版信息

Intern Med J. 2011 Apr;41(4):354-7. doi: 10.1111/j.1445-5994.2011.02457.x.

DOI:10.1111/j.1445-5994.2011.02457.x

Abstract

Neurosarcoidosis can worsen despite standard immunosuppressive therapy, a situation for which there is no established medical management. We present three cases of medically refractory neurosarcoidosis treated with infliximab. All three patients showed a clinical response to this treatment and side effects were limited. A summary of reported cases of neurosarcoidosis treated with infliximab is included. This case series supports a role for infliximab in the treatment of patients with medically refractory neurosarcoidosis.

摘要

神经结节病尽管采用标准的免疫抑制疗法仍可能恶化，而针对这种情况目前尚无既定的医学治疗方法。我们报告了三例采用英夫利昔单抗治疗的药物难治性神经结节病。所有三名患者对该治疗均表现出临床反应，且副作用有限。本文还包括了采用英夫利昔单抗治疗的神经结节病病例报告总结。该病例系列研究支持英夫利昔单抗在治疗药物难治性神经结节病患者中的作用。