Seifert M, Eichler W, Fiebig H
Bereich Tierphysiologie und Immunbiologie, Karl-Marx-Universität Leipzig.
Allerg Immunol (Leipz). 1990;36(4):267-76.
This study presents two murine monoclonal antibodies which react with the Common Acute Lymphoblastic Leukemia Antigen (CALLA). Both antibodies can be used for the diagnosis of common ALL (cALL). Indirect immunofluorescence studies (FACS-analysis) showed that the antibodies react with granulocytes and different human cell lines (Nalm-6, Reh, Raji, CCRF-CEM). The monoclonal antibodies BL-CALLA/1 and BL-CALLA/2 identify a single polypeptide chain of 95 kD. Both antibodies recognize the same or closely related epitope of the CALLA-molecule and are able to modulate in vitro the antigen on the CALLA-positive cell line Reh.
本研究展示了两种与常见急性淋巴细胞白血病抗原（CALLA）发生反应的鼠单克隆抗体。这两种抗体均可用于诊断常见急性淋巴细胞白血病（cALL）。间接免疫荧光研究（流式细胞仪分析）表明，这些抗体可与粒细胞及不同的人类细胞系（Nalm-6、Reh、Raji、CCRF-CEM）发生反应。单克隆抗体BL-CALLA/1和BL-CALLA/2识别一条95 kD的单一多肽链。两种抗体识别CALLA分子的相同或密切相关表位，并且能够在体外调节CALLA阳性细胞系Reh上的抗原。
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