破解组合性 semaphorin 密码。

Cracking the combinatorial semaphorin code.

机构信息

Molecular, Cellular, and Developmental Biology Department, Yale University, POB 208103, New Haven, CT 06520-8103, USA.

出版信息

Neuron. 2011 Apr 28;70(2):175-7. doi: 10.1016/j.neuron.2011.04.010.

DOI:10.1016/j.neuron.2011.04.010

Abstract

In this issue of Neuron, Wu et al. describe a combinatorial code of repulsive Sema-2a and attractive Sema-2b signaling that mediates mechanosensory axonal guidance, fasciculation, and synaptic target selection within the CNS of Drosophila. Their work exemplifies how a detailed, multilevel molecular-genetic analysis (from molecules to behavior) provides fundamental insights into neural circuit development.

摘要

在本期《神经元》杂志中，Wu 等人描述了排斥性 Sema-2a 和吸引性 Sema-2b 信号的组合编码，该编码介导了果蝇中枢神经系统中的机械敏感轴突导向、纤维形成和突触靶选择。他们的工作很好地说明了详细的多层次分子遗传学分析（从分子到行为）如何为神经回路发育提供了基本的见解。