红带锥蝽马氏管液和尿液中的环磷酸腺苷
Cyclic AMP in the Malpighian tubule fluid and in the urine of Rhodnius prolixus.
作者信息
Montoreano R, Triana F, Abate T, Rangel-Aldao R
机构信息
Centro de Investigaciones Biomédicas (BIOMED), Universidad de Carabobo, Maracay, Venezuela.
出版信息
Gen Comp Endocrinol. 1990 Jan;77(1):136-42. doi: 10.1016/0016-6480(90)90214-7.
We demonstrate the presence of cyclic adenosine monophosphate (cAMP) in the fluid secreted by isolated Malpighian tubules of Rhodnius prolixus. In addition, we show that fifth-instar R. prolixus excrete cAMP in the urine after a meal of human blood. Nonstimulated isolated Malpighian tubules secrete small amounts of cAMP that increase about 10-fold after the addition of 5-hydroxytryptamine (5-HT). 5-HT is known to mimic R. prolixus diuretic hormone. The present findings demonstrate that 5-HT also acts via cAMP. The presence of cAMP in the rectal sac of the insect could be of importance in the differentiation of Trypanosoma cruzi and in the cycle of Chagas disease.
我们证实了在红带锥蝽离体马氏管分泌的液体中存在环磷酸腺苷（cAMP）。此外，我们还表明，吸食人血后的五龄红带锥蝽会在尿液中排泄cAMP。未受刺激的离体马氏管分泌少量cAMP，添加5-羟色胺（5-HT）后其分泌量增加约10倍。已知5-HT可模拟红带锥蝽利尿激素。目前的研究结果表明，5-HT也通过cAMP发挥作用。昆虫直肠囊中cAMP的存在可能对克氏锥虫的分化以及恰加斯病的传播周期具有重要意义。
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