Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
Trends Immunol. 2011 Jul;32(7):315-20. doi: 10.1016/j.it.2011.03.009. Epub 2011 Apr 29.
In the bone marrow, hematopoietic stem cells (HSCs) are maintained by special microenvironments, termed niches. The nature and function of these niches, however, remains unclear. HSCs are thought be in contact with bone-lining osteoblasts, but recent studies have suggested that only a small subpopulation of HSCs reside in this endosteal niche. By contrast, many HSCs are associated with the sinusoidal endothelium, which is referred to as the vascular niche. Recent data have suggested that primitive mesenchymal cells, including CXC chemokine ligand 12-abundant reticular cells and nestin-expressing cells act as HSC niches. Here, we review HSC niches, with an emphasis on the emerging role of reticular niches for maintaining HSCs in a proliferative and undifferentiated state.
在骨髓中，造血干细胞（HSCs）被称为龛的特殊微环境所维持。然而，这些龛的性质和功能尚不清楚。HSCs 被认为与衬里成骨细胞接触，但最近的研究表明，只有一小部分 HSCs 存在于这个骨内膜龛中。相比之下，许多 HSCs 与窦状内皮细胞有关，后者被称为血管龛。最近的数据表明，原始间充质细胞，包括 CXCL12 丰富的网状细胞和巢蛋白表达细胞，作为 HSC 龛发挥作用。在这里，我们综述了 HSC 龛，重点介绍了网状龛在维持 HSCs 增殖和未分化状态中的新兴作用。
