哌唑嗪对脊髓麻醉大鼠突触前和突触后α受体的作用。
The effect of prazosin of pre- and post-synaptic alpha-receptors in the pithed rat.
作者信息
Hua A S, Moulds R F
出版信息
Clin Exp Pharmacol Physiol. 1978 Sep-Oct;5(5):525-8. doi: 10.1111/j.1440-1681.1978.tb00705.x.
Abstract
- Prazosin had a marked inhibitory effect on post-synaptic alpha-receptors in the pithed rat, as measured by the blood pressure response to the cumulative administration of clonidine. 2. Prazosin had no inhibitory effect, however, on the pre-synaptic alpha-receptor, as measured by the clonidine-induced reduction in the tachycardia produced by stimulation of the cardiac nerves. 3. These results suggest that prazosin has a selective antagonistic affinity for post-synaptic alpha-receptors.
摘要
- 哌唑嗪对脊髓麻醉大鼠的突触后α受体有显著抑制作用，这是通过可乐定累积给药后的血压反应来衡量的。2. 然而，通过可乐定诱导刺激心脏神经所产生的心动过速的降低来衡量，哌唑嗪对突触前α受体没有抑制作用。3. 这些结果表明哌唑嗪对突触后α受体具有选择性拮抗亲和力。
相似文献
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The effect of prazosin of pre- and post-synaptic alpha-receptors in the pithed rat.哌唑嗪对脊髓麻醉大鼠突触前和突触后α受体的作用。
Clin Exp Pharmacol Physiol. 1978 Sep-Oct;5(5):525-8. doi: 10.1111/j.1440-1681.1978.tb00705.x.
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