Udalova Irina A, Ruhmann Michaela, Thomson Scott J P, Midwood Kim S
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, United Kingdom.
Crit Rev Immunol. 2011;31(2):115-45. doi: 10.1615/critrevimmunol.v31.i2.30.
Our immune system is designed to protect us from danger. Upon pathogen invasion and tissue injury, activation of both innate and adaptive immunity enables us to combat infection and to repair tissue damage. Tenascin-C is a large, extracellular matrix glycoprotein that has a very tightly controlled pattern of expression. Little or no tenascin-C is expressed in most healthy adult tissues; however, it is rapidly and transiently induced at sites of tissue injury and infection. Persistent tenascin-C expression is associated with pathologies such as chronic, non-healing wounds, autoimmune diseases, cancer, and fibrotic diseases. We discuss the myriad roles that this multifunctional molecule plays during the immune response, with a focus on how tissue levels of tenascin-C are regulated and the consequences of misregulated tenascin-C expression in immune regulated disease pathogenesis.
我们的免疫系统旨在保护我们免受危险。在病原体入侵和组织损伤时，固有免疫和适应性免疫的激活使我们能够对抗感染并修复组织损伤。腱生蛋白-C是一种大型细胞外基质糖蛋白，其表达模式受到严格控制。在大多数健康成人组织中，腱生蛋白-C很少或不表达；然而，它在组织损伤和感染部位会迅速且短暂地被诱导表达。腱生蛋白-C的持续表达与慢性难愈性伤口、自身免疫性疾病、癌症和纤维化疾病等病理状况相关。我们讨论了这种多功能分子在免疫反应中所起的众多作用，重点关注腱生蛋白-C的组织水平是如何被调节的，以及在免疫调节疾病发病机制中腱生蛋白-C表达失调的后果。
