Institute of Physiology I/Neurophysiology, Jena University Hospital-Friedrich Schiller University, Teichgraben 8, D-07740 Jena, Germany.
Arthritis Res Ther. 2011 Apr 28;13(2):210. doi: 10.1186/ar3305.
The peripheral nociceptor is an important target of pain therapy because many pathological conditions such as inflammation excite and sensitize peripheral nociceptors. Numerous ion channels and receptors for inflammatory mediators were identified in nociceptors that are involved in neuronal excitation and sensitization, and new targets, beyond prostaglandins and cytokines, emerged for pain therapy. This review addresses mechanisms of nociception and focuses on molecules that are currently favored as new targets in drug development or that are already targeted by new compounds at the stage of clinical trials--namely the transient receptor potential V1 receptor, nerve growth factor, and voltage-gated sodium channels--or both.
外周伤害感受器是疼痛治疗的一个重要靶点，因为许多病理状况，如炎症，会兴奋和敏化外周伤害感受器。在伤害感受器中已经鉴定出许多与神经元兴奋和敏化有关的离子通道和炎症介质受体，除了前列腺素和细胞因子之外，还出现了新的疼痛治疗靶点。这篇综述探讨了伤害感受的机制，并重点介绍了目前在药物开发中被视为新靶点的分子，或者在临床试验阶段已经被新化合物针对的分子，即瞬时受体电位 V1 受体、神经生长因子和电压门控钠离子通道，或者两者兼而有之。
