Iwami Momoe, Shiina Takahiko, Hirayama Haruko, Shimizu Yasutake
Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Japan.
Biomed Res. 2011 Apr;32(2):181-5. doi: 10.2220/biomedres.32.181.
Zingerone, a pungent component of ginger, may exert beneficial therapeutic effects on hypermotility-induced diarrhea because it has the ability to inhibit contractions of colonic smooth muscles. However, the pungency is undesirable for possible therapeutic use. The purpose of this study was to examine effects of zingerol, a non-pungent analogue of zingerone, in rats. Colonic motility in vivo was evaluated by measuring intraluminal pressure changes and expelled fluid volume from the colon in anesthetized rats. Mechanical contractile activities of isolated colonic segments were also recorded. Intracolonic administration of zingerol attenuated colonic motility in vivo without affecting blood pressure and heart rate in a manner similar to that of zingerone. Zingerol also inhibited spontaneous contractile movements in isolated colonic segments, suggesting that zingerol directly acts on the colon. Zingerol had no effect on jejunal motility, although zingerone showed an inhibitory effect to the jejunum. These findings suggest that zingerol can inhibit colonic motility without adverse effects on small intestinal motility and the cardiovascular system. The non-pungent property of zingerol will be useful as an oral or suppository medicine for treating diarrhea and other gastrointestinal disorders.
姜辣素是生姜中的一种辛辣成分，可能对肠道运动亢进引起的腹泻发挥有益的治疗作用，因为它能够抑制结肠平滑肌的收缩。然而，这种辛辣味对于可能的治疗用途来说并不理想。本研究的目的是检测姜烯酚（姜辣素的一种无辛辣味类似物）对大鼠的影响。通过测量麻醉大鼠的肠腔内压力变化和结肠排出的液体量来评估体内结肠运动。还记录了离体结肠段的机械收缩活动。结肠内给予姜烯酚可减弱体内结肠运动，且不影响血压和心率，其作用方式与姜辣素相似。姜烯酚还抑制离体结肠段的自发收缩运动，表明姜烯酚直接作用于结肠。姜烯酚对空肠运动没有影响，而姜辣素对空肠有抑制作用。这些发现表明，姜烯酚可以抑制结肠运动，而对小肠运动和心血管系统没有不良影响。姜烯酚的无辛辣味特性将有助于作为口服或栓剂药物治疗腹泻和其他胃肠道疾病。
