Kiaris H, Spandidos D
NATL HELLEN RES FND, INST BIOL RES & BIOTECHNOL, GR-11635 ATHENS, GREECE. UNIV CRETE, SCH MED, IRAKLION, GREECE.
Int J Oncol. 1995 Sep;7(3):413-21.
Ras family genes (H-, K- and N-ras) are implicated in a wide range of human rumours. Mutations are a major activating mechanism for the ras family genes, mainly in codons 12, 13 and 61, resulting in their conversion from proto-oncogenes to activated oncogenes. The detection of mutant ras alleles in human tumours has been performed by several investigators in a wide range of tissues. The aim of our review was to summarize the data obtained from these studies and to investigate whether the presence of mutant ras alleles was associated with particular clinical parameters.
Ras家族基因（H-Ras、K-Ras和N-Ras）与多种人类肿瘤相关。突变是Ras家族基因的主要激活机制，主要发生在密码子12、13和61处，导致它们从原癌基因转变为激活的癌基因。多位研究者已在多种组织中对人类肿瘤中的突变Ras等位基因进行了检测。我们综述的目的是总结这些研究获得的数据，并调查突变Ras等位基因的存在是否与特定临床参数相关。
