Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Japan.
Immunogenetics. 2011 Aug;63(8):501-9. doi: 10.1007/s00251-011-0531-y. Epub 2011 May 7.
Natural-killer group 2 member D (NKG2D) is an activating receptor that plays an important role in the immune response mediated by NK cells, γδ(+) T cells, and CD8(+) T cells. In humans, MHC class I chain-related genes and UL-16 binding protein (ULBP)/retinoic acid early transcript 1 (REAT1) gene family encode ligands for NKG2D. The rhesus and crab-eating macaques, which belong to the Old World monkeys, are widely used as non-human primate models in medical researches on the immunological process. In the present study, we investigated the polymorphisms of ULBP4/RAET1E, a member of the ULBP/RAET1 family, and found 25 and 14 alleles from the rhesus and crab-eating macaques, respectively, of which diversities were far more extended than in humans. A phylogenetic study suggested that the allelic diversification of ULBP4/RAET1E predated the divergence of rhesus and crab-eating macaques.
自然杀伤细胞群 2 成员 D（NKG2D）是一种激活受体，在 NK 细胞、γδ(+)T 细胞和 CD8(+)T 细胞介导的免疫反应中发挥重要作用。在人类中，MHC Ⅰ类链相关基因和 UL-16 结合蛋白（ULBP）/维甲酸早期转录物 1（REAT1）基因家族编码 NKG2D 的配体。猕猴和食蟹猴属于旧世界猴，广泛用作医学免疫过程研究中的非人灵长类模型。本研究调查了 ULBP4/RAET1E（ULBP/RAET1 家族的一个成员）的多态性，分别从猕猴和食蟹猴中发现了 25 个和 14 个等位基因，其多样性远高于人类。系统发育研究表明，ULBP4/RAET1E 的等位基因多样化先于猕猴和食蟹猴的分化。
