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Synthesis and Evaluation of Noviose Replacements on Novobiocin that Manifest Anti-proliferative Activity.
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To fold or not to fold: modulation and consequences of Hsp90 inhibition.
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Alternate strategies of Hsp90 modulation for the treatment of cancer and other diseases.
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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.
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Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.
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The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.
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Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines.
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Hsp90: a novel target for the disruption of multiple signaling cascades.
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