Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Diabetes Obes Metab. 2011 Sep;13(9):863-5. doi: 10.1111/j.1463-1326.2011.01420.x.
Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers [body mass index (BMI) >30 kg/m(2) ; n = 12] and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat versus protein. However, the total 300-min GIP response was greater after fat than after protein ingestion (20.3 ± 3.9 vs. 10.0 ± 2.8 nmol/l × min; p = 0.026), whereas the 300-min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300-min GIP secretion is more pronounced after fat than protein ingestion.
在瘦人中，蛋白质比脂肪摄入能更早（30 分钟）引发更强的葡萄糖依赖性胰岛素释放肽（GIP）反应，而胰高血糖素样肽-1（GLP-1）则没有差异。我们评估了肥胖人群中蛋白质与脂肪摄入对肠促胰岛素激素的反应。非糖尿病肥胖男性志愿者（体重指数（BMI）>30 kg/m²；n=12）摄入等热量（8 kcal/kg）的脂肪（橄榄油）或蛋白质（乳清蛋白），并测定血浆 GIP 和 GLP-1。我们发现脂肪与蛋白质相比，早期 GIP 或 GLP-1 反应没有差异。然而，脂肪摄入后的总 300 分钟 GIP 反应大于蛋白质摄入后的反应（20.3±3.9 与 10.0±2.8 nmol/l×min；p=0.026），而 300 分钟 GLP-1 反应相同。因此，在肥胖中，蛋白质和脂肪摄入引发相似的早期（30 分钟）肠促胰岛素激素反应，而脂肪摄入后 300 分钟 GIP 分泌更为明显。
