Nakashima K, Takahashi K
Division of Neurology, Tottori University School of Medicine, Yonago, Japan.
Electromyogr Clin Neurophysiol. 1990 Feb-Mar;30(2):105-8.
Sensory nerve action potentials (SNAP) and mixed nerve action potentials (MNAP) of the median nerve were examined in 16 patients with motor neurone disease (MND), 29 patients with peripheral neuropathy and 18 age-matched normal controls. Patients with MND showed almost normal amplitudes of SNAP and MNAP, though they had muscle weakness in the hands. The motor nerve fibres may have a negligible effect on MNAP. The amplitude of MNAP correlated well with that of SNAP. The sensory fibres may play a major role in MNAP. Patients with peripheral neuropathy showed a significant reduction in amplitude in SNAP and MNAP. In particular, patients with sensory disturbance in the hands elicited low amplitudes in SNAP and MNAP. Patients without sensory disturbance also showed a decrease in amplitude in SNAP and MNAP. Peripheral neuropathy patients without sensory disturbance might show subclinical disturbance of peripheral sensory nerve fibres.
对16例运动神经元病（MND）患者、29例周围神经病患者及18例年龄匹配的正常对照者进行了正中神经感觉神经动作电位（SNAP）和混合神经动作电位（MNAP）检测。MND患者手部虽有肌肉无力，但SNAP和MNAP的波幅几乎正常。运动神经纤维对MNAP的影响可能微不足道。MNAP的波幅与SNAP的波幅相关性良好。感觉纤维可能在MNAP中起主要作用。周围神经病患者的SNAP和MNAP波幅明显降低。特别是手部有感觉障碍的患者，其SNAP和MNAP波幅较低。无感觉障碍的患者SNAP和MNAP波幅也降低。无感觉障碍的周围神经病患者可能存在周围感觉神经纤维的亚临床损害。
